Optical properties of biotissues in vivo and ex vivo

Advanced Biophotonics LaboratoryResearch Directions Optical properties of biotissues in vivo and ex vivo
X. Feng, R. Patel and A. N. Yaroslavsky, "Wavelength optimized cross‐polarized wide‐field imaging for noninvasive and rapid evaluation of dermal structures," J. Biophoton 8(1), 324-331 (2015)
X. Feng, R. Patel and A. N. Yaroslavsky, "Wavelength optimized cross‐polarized wide‐field imaging for noninvasive and rapid evaluation of dermal structures," J. Biophoton 8(1), 324-331 (2015)
E. Salomatina and A.N. Yaroslavsky. "Evaluation of the in vivo and ex vivo optical properties in a mouse ear model," Phys. Med. Biol. 58, 2797 (2008).
E. Salomatina and A.N. Yaroslavsky. "Evaluation of the in vivo and ex vivo optical properties in a mouse ear model," Phys. Med. Biol. 58, 2797 (2008).

Optical properties of biological turbid media can be determined using integrating sphere and goniometer-based experimental techniques. We use these methods to investigate light scattering and absorption by complex biological tissues and data-processing algorithms to reconstruct the optical properties from measured data. This work provides accurate spectrally resolved absorption and scattering coefficients of normal and pathological tissues and enables accurate dosimetry of light and laser-based treatments.

 

Selected Publications:

  1. Yao M, Henry FP., Yaroslavsky AN, Redmond RW, and Kochevar IE, “Phototoxicity is not associated with photochemical tissue bonding of skin,” Las Surg Med. 42(2), 123-131 (2010).
  2. Salomatina E, and Yaroslavsky AN, “Evaluation of the in vivo and ex vivo optical properties in a mouse ear model,” Phys Med Biol. 53(11), 2797-2807 (2008).
  3. Chan BP, Hui TY, Chan CM, So K-F, Lu W, Cheung KMC, Salomatina E, and Yaroslavsky A, “Photochemical crosslinking for collagen-based scaffolds – A study on optical properties, mechanical properties, stability and haematocompatibility,” Tissue Engineering. 13(1), 73-84 (2007).
  4. Salomatina E, Jiang B, Novak J, and Yaroslavsky AN, “Optical properties of normal and cancerous human skin in the visible and near infrared spectral range,” J Biomed Opt. 11(6), 064026 (2006).
  5. Anderson RR, Farinelli W, Laubach H, Manstein D, Yaroslavsky AN, Gubeli III J, Jordan K, Neil GR, Shinn M, Chandler W, Williams GP, Benson SV, and Dylla HF, “Selective photothermolysis of lipid-rich issues: a free electron laser study,” Las Surg Med. 38(10), 913-919 (2006).
  6. Yaroslavsky AN, Schulze PC, Yaroslavsky IV, Schober R, Ulrich F, and Schwarzmaier HJ, “Optical properties of selected native and coagulated human brain tissues in vitro in the visible and near infrared spectral range,” Phys Med Biol. 47(12), 2059-2073 (2002).
  7. Yaroslavsky IV, Yaroslavsky AN, Goldbach T, Schwarzmaier HJ, “Inverse hybrid technique for the determination of the optical properties of turbid media,” Appl Opt. 35(34), 6797-6809 (1996).
  8.  Yaroslavsky AN, Yaroslavsky IV, Goldbach T, Schwarzmaier HJ, “Optical properties of blood in the near-infrared spectral range,” Proc.   SPIE 2678, Optical Diagnostics of Living Cells and Biofluids,(10 May 1996); doi: 10.1117/12.239516