Modeling of light propagation in tissues

Advanced Biophotonics LaboratoryResearch Directions Modeling of light propagation in tissues
A. N. Yaroslavsky, I. V. Yaroslavsky, T. Goldbach, and H.-J. Schwarzmaier, "Influence of the scattering phase function approximation on the optical properties of blood determined from the integrating sphere measurements," J. Biomed. Opt. 4(1), (1999).
A. N. Yaroslavsky, I. V. Yaroslavsky, T. Goldbach, and H.-J. Schwarzmaier, "Influence of the scattering phase function approximation on the optical properties of blood determined from the integrating sphere measurements," J. Biomed. Opt. 4(1), (1999).
Hammer M, Yaroslavsky AN, and Schweitzer D, “A scattering phase function for blood with physiological hematocrit,” Phys Med Biol. 46, 65-69 (2001).
Hammer M, Yaroslavsky AN, and Schweitzer D, “A scattering phase function for blood with physiological hematocrit,” Phys Med Biol. 46, 65-69 (2001).

The aim of this research is to develop accurate dosimetry of light treatments and planning for low level light therapy by utilizing Monte Carlo simulation of light propagation in complex biological tissues. Knowledge of transport parameters including absorption coefficient and reduced scattering coefficient enables individualized treatments for portwine stains, fat removal, and interstitial thermotherapy of cancer, as well as optimal application of photobiomodulation therapy (PBMT).

 

Selected Publications:

  1. Demidova-Rice TN, Salomatina E, Yaroslavsky AN, Herman IM, and Hamblin MR, “Low-level light stimulates excisional wound healing in mice,” Las Surg Med. 39(9) 716-722 (2007).
  2. Yang MU, Yaroslavsky AN, Farinelli WA, Flotte TJ, Rius-Diaz F, Tsao SS, and Anderson RR, “Long-pulsed neodymium:yttrium-aluminum-garnet laser treatment for portwine stains,” JAAD. 52(3), 480-490 (2005).
  3. Chan BP, Amann C, Yaroslavsky AN, Title C, Smink D, Zarins B, Kochevar IE, and Redmond RW, “Photochemical repair of achilles tendon rupture in a rat model,” J Surg Res. 124(2), 274-279 (2004).
  4. Hammer M, Yaroslavsky AN, and Schweitzer D, “A scattering phase function for blood with physiological hematocrit,” Phys Med Biol. 46, 65-69 (2001).
  5. Yaroslavsky I, Yaroslavsky A, Battarbee H, Sisson C, and Rodriguez J, “Self-calibrating distributed source image reconstruction technique for diffuse optical tomography,” Trends in Optics and Photonics. 38, 487-489 (2000).
  6. Willmann S, Terenji A, Busse H, Yaroslavsky IV, Yaroslavsky AN, Schwarzmaier HJ, and Hering P, “Scattering delay time of Mie scatterers determined from steady-state and time-resolved optical spectroscopy,” J Opt Soc Am A. 17(4), 745-749 (2000).
  7. Yaroslavsky AN, Yaroslavsky IV, Goldbach T, and Schwarzmaier HJ, “Influence of the scattering phase function approximation on the optical properties of blood determined from the integrating sphere measurements,” J B M O. 4(01), 47-53 (1999).
  8. Yaroslavsky AN, Yaroslavsky IV, Otto C, Puppels GJ, Duindam H, Vrensen GFJM, Greve J, and Tuchin VV, “Water exchange in human eye lens monitored by the confocal Raman microspectroscopy,” Biophysics. 43(1), 125-130 (1998).
  9. Yaroslavsky IV, Yaroslavsky AN, and Tuchin VV, “Schwarzmaier H-J. Effect of the scattering delay on time-dependent photon migration in turbid media,” Appl Opt. 36(25), 6529-6538 (1997).
  10. Schwarzmaier HJ, Yaroslavsky IV, Yaroslavsky AN, Fiedler V, Ulrich F, and Kahn T, “Treatment planning for MRI-guided laser-induced interstitial thermotherapy of brain tumors – the role of blood perfusion,” J M R I. 8(1), 121-127 (1998).
  11. Yaroslavsky IV, Yaroslavsky AN, Otto C, Puppels GJ, Vrensen GFJM, Duindam H, Greve J, “Combined elastic and Raman scattering of human eye lenses,” Exp Eye Res. 59(4), 393-400 (1994).