Intraoperative delineation of cancers in vivo and ex vivo

Advanced Biophotonics LaboratoryResearch Directions Intraoperative delineation of cancers in vivo and ex vivo
Patel R, Khan A, Wirth D, Kamionek M, Kandil D, Quinlan R, and Yaroslavsky AN, “Multimodal optical imaging for detecting breast cancer,” J. Biomed. Opt. 17(6), (2012).
Patel R, Khan A, Wirth D, Kamionek M, Kandil D, Quinlan R, and Yaroslavsky AN, “Multimodal optical imaging for detecting breast cancer,” J. Biomed. Opt. 17(6), (2012).
Rohani P, Yaroslavsky AN, Feng X, Jermain P, and Neel V, “Collagen disruption as a marker for basal cell carcinoma in presurgical margin detection,” Lasers Surg Med. (2018).
Rohani P, Yaroslavsky AN, Feng X, Jermain P, and Neel V, “Collagen disruption as a marker for basal cell carcinoma in presurgical margin detection,” Lasers Surg Med. (2018).

Multimodal optical imaging is useful for the intraoperative detection and demarcation of tumor boundaries in various pathologies. The goal of  this research is to develop steady-state and time-resolved polarization, fluorescence, fluorescence polarization, and elastic scattering methods and devices to delineate cancers in vivo and ex vivo. This technology will enable rapid inspection of surgical margins at various spatial scales to facilitate complete resection of the cancerous lesion.

 

Selected Publications:

  1. Rohani P, Yaroslavsky AN, Feng X, Jermain P, and Neel V, “Collagen disruption as a marker for basal cell carcinoma in presurgical margin detection,” Lasers Surg Med. (2018).
  2. Yaroslavsky A.N, Joseph C, Patel R, Muzikansky A, Neel V, and Giles R, “Delineating nonmelanoma skin cancer margins using terahertz and optical imaging,” J. Biophoton. and Eng. (2017).
  3. Yaroslavsky AN, and Feng X, Neel V, “Optical mapping of nonmelanoma skin cancers – A pilot clinical study,” Lasers Surg Med. 49(9), 803-809 (2017).
  4. Patel R, Khan A, Quinlan R, and Yaroslavsky AN, “Polarization sensitive multimodal imaging for detecting breast cancer,” Cancer Res. (2014).
  5. Patel R, Khan A, Kandil D, Kamionek M, Quinlan R, and Yaroslavsky AN, “Delineating breast ductal carcinoma using combined dye-enhanced wide-field polarization imaging and optical coherence tomography,” J. Biophoton. 6(9), 679-686 (2013).
  6. Joseph CS, Patel R, Neel V, Giles RH, and Yaroslavsky AN, “Imaging of ex vivo nonmelanoma skin cancers in the optical and terahertz spectral regions,” J. Biophoton. 1–10 (2012).
  7. Patel R, Khan A, Wirth D, Kamionek M, Kandil D, Quinlan R, and Yaroslavsky AN, “Multimodal optical imaging for detecting breast cancer,” J. Biomed. Opt. 17(6), (2012).
  8. Yaroslavsky AN, Patel R, Salomatina E, Li C, Lin C, Al-Arashi M, and Neel V, “High contrast mapping of basal cell carcinomas,” Optics Letters. 37(4), (2012).
  9. Joseph C, Yaroslavsky AN, Neel V, Goyette T, and Giles R, “Continuous wave terahertz transmission imaging of nonmelanoma skin cancers,” Las. Surg. Med. 43, 457–462 (2011).
  10. Salomatina E, Muzikansky A, Neel V, Yaroslavsky AN, “Multimodal optical imaging and spectroscopy for the intraoperative mapping of nonmelanoma skin cancer,” J Appl Phys. 105(10), 102010-102017 (2009).
  11. Tannous Z, Al-Arashi M, Shah S, and Yaroslavsky AN, “Delineating melanoma using multimodal polarized light imaging,” Las Surg Med. 41(1), 10-16 (2009).
  12. Yaroslavsky AN, Salomatina EV, Neel V, Anderson R, and Flotte T, “Fluorescence Polarization of Tetracycline Derivatives as a Technique for Mapping Nonmelanoma Skin Cancers,” J Biomed Opt. 12(1) 014005. (2007).
  13. Yaroslavsky AN, Barbosa J, Neel V, DiMarzio C, and Anderson RR, “Combining multi-spectral polarized-light imaging and confocal microscopy for localization of nonmelanoma skin cancer,” J Biomed Opt. 10(1), 014011 (2005).
  14. Yaroslavsky AN, Neel V, and Anderson RR, “Fluorescence polarization imaging for delineating nonmelanoma skin cancers,” Optics Letters. 29(14), 2010-2012 (2004).
  15. Yaroslavsky AN, Neel V, and Anderson RR, “Demarcation of nonmelanoma skin cancer margins using multi-spectral polarized-light imaging,” J Invest Dermatol. 121(2), 259-266 (2003).