• S Sha, Z Huang, Z Wang, S Yoon (2018), Mechanistic modeling and applications for CHO cell culture development and production, Current Opinion in Chemical Engineering 22, 54-61,
  • SC Galbraith, H Bhatia, H Liu, S Yoon (2018), Media formulation optimization: current and future opportunities, Current Opinion in Chemical Engineering 22, 42-47,
  • Adam C. Fisher1*, Mark-Henry Kamga2*, Sau L. Lee1, Seongkyu Yoon2†, and Kurt Brorson1† (2018), The Current Scientific and Regulatory Landscape in Advancing Integrated Continuous Biopharmaceutical Manufacturin, Trends in Biotechnology,
  • Sha, S., B. Bhatia, and Yoon* (2018), An RNAseq based transcriptomic investigation of Chinese Hamster Ovary cells with variant productivity and growth, Journal of Biotechnology
  • Mora, A., S. Zhang, G. Carson, B. Nabiswa, P. Hossler, S. Yoon (2018), Sustaining an efficient and effective CHO cell line development platform by incorporation of 24-deep well plate screening and multivariate analysis, Biotechnology Progress, 34(1), 175-186, 1002/btpr.2584
  • Park, S.-Y., Reimonn, T. M., Agarabi, C., Brorson, K. and Yoon, S. (2018), Metabolic responses and pathway changes of mammalian cells under different culture conditions with media supplementations. Biotechnology Progress, 1002/btpr.2623
  • Liu, Huolong, Shaun Galbraith, Bumjoon Cha, Zhuangrong Huang, Seoyoung Park, Meyer, R., Flamm, M., O’Connor Thomas, Lee, Sau, Yoon, S., (2018), Development of a three-compartmental population balance model for a continuous twin screw wet granulation process, Pharmaceutical Development and Technology org/10.1080/10837450.2018.1427106
  • Seo-Young Park, Shaun C Galbraith, Bumjoon Cha, Huolong Liu, Zhuangrong Huang, HaeWoo Lee, Thomas O’Connor, Sau Lee, Seongkyu Yoon, (2018) Prediction of critical quality attributes and optimization of continuous dry granulation process via flowsheet modeling and experimental validation, Powder Technology,


  • Liu, Huolong, Yoon, S. *, (2017), A Real-time optimization strategy of a pulsed-spray fluidized bed granulation process based on three-stage population balance model, Powder Technology, / ,
  • Velugula-Yellela, S., A. Williams, N. Trunfio, C. Hsu, B. Chavez, S. Yoon and C. Agarabi, (2017), Impact of media and antifoam selection on monoclonal antibody production and quality using a high throughput micro-bioreactor system, Biotechnology Progress, 1002/btpr.2575
  • Kyriakopoulos, S., M. Lakshmanan, K. Ang, Z. Huang, S. Yoon, Huang, R. Gunawan, D. Lee (2017), Kinetic modeling of mammalian cell culture bioprocessing, Biotechnology Journal, 10.1002/biot.201700229
  • Bhatia, H., H. Mehdizadeh, D. Drapeau, S. Yoon, and M. Moshgbar* (2017), Quantitation of Amino Acids in Cell Cultures using Raman Spectroscopy, Engineering In Life Sciences, 18(1), 1002/elsc.201700084
  • Galbraith, S.C. Zhuangrong Huang, Bumjoon Cha. Hurley Liu, Huolong, and S. Yoon *, (2017), Modeling and simulation of continuous powder blending applied to a continuous direct compression process, Pharmaceutical Development and Technology (Accepted on Dec 24, 2017), org/10.1080/10837450.2018.1425429
  • Kamga, M., Roper T, Padye S, Li Y, Cattaneo M, and Seongkyu Yoon * (2017), Integrated continuous biomanufacturing platform with ATF perfusion and one column chromatography operation, Preparative Chromatography and Biopharmaceutical, org/10.1080/10826068.2018.1446151
  • Trunfio, N., Lee, H., Starkey, J., Agarabi, C., Liu, J. and Yoon, S. * (2017), Characterization of Mammalian Cell Culture Raw Materials by Combining Spectroscopy and Chemometrics. Biotechnol Progress. doi:10.1002/btpr.2480
  • Liu, Huolong, Galbraith, S.C., Ricart, Brendon, Stanton, Courtney, Smith-Goettler, Brandye, Verdi, Luke, O’Connor, Thomas, Lee, Sau, Yoon, Seongkyu* (2017), Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data. International Journal of Pharmaceutics, 525(1), 249-263,
  • Behere, Ketki, B. Cha, and Yoon* (2017), Protein A resin lifetime study: evaluation of protein A performance with a model based approach in continuous capture, Preparative Chromatography and Biopharmaceutical, /doi/full/10.1080/10826068.2018.1425711
  • Huang, Zhuangrong, D. Lee, and Yoon* (2017), Huang Z, Lee D-Y, Yoon S. Quantitative intracellular flux modeling and applications for biotherapeutic development and production using CHO cell cultures. Biotechnology and Bioengineering. 2017;1–12.
  • Liu, Huolong, Shaun Galbraith, Bumjoon Cha, Zhuangrong Huang, Seoyoung Park, and Seongkyu Yoon (2017), Online optimal control of a fluidized bed spary granulation process based on a three-phase population balance model FOCAPD Conference Proceeding
  • Galbraith, S.C. Zhuangrong Huang, Bumjoon Cha. Hurley Liu, Huolong, and S. Yoon*, (2017), Flowsheet modeling of a continuous direct compression tableting process at production. FOCAPD Conference Proceeding
  • Huolong Liu, Seongkyu Yoon & Mingzhong Li (2016): Three-dimensional computational fluid dynamics (CFD) study of the gas–particle circulation pattern within a fluidized bed granulator: By full factorial design of fluidization velocity and particle size, Drying Technology, DOI: 10.1080/07373937.2016.1230628
  • Bhatia H, Read E, Agarabi C, Brorson K, Lute S, Yoon S. * (2016), A design space exploration for control of Critical Quality Attributes of mAb. Int J Pharm. 2016 Oct 15; 512(1):242-52. PMID: 27575657.
  • Bhatia H, Read E, Agarabi C, Brorson K, Lute S, Yoon S. * (2016), Hybridoma cell-culture and glycan profile dataset at various bioreactor conditions. Data Brief. 2016 Dec; 9:676-678. PMID: 27790631.
  • Reimonn TM, Park SY, Agarabi CD, Brorson KA, Yoon S. * (2016), Effect of amino acid supplementation on titer and glycosylation distribution in hybridoma cell cultures-Systems biology-based interpretation using genome-scale metabolic flux balance model and multivariate data analysis. Biotechnol Prog. 2016 Sep; 32(5):1163-1173. PMID: 27452371.
  • Sha, , C. Agarabi, K. Brorson, and S. Yoon* (2016), N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies, Trends in Biotechnology.


  • Dong Ho Park, Hyo Sung Jeon, Soo Young Lee, Yi Young Choi, Hae Woo Lee, Seongkyu Yoon, Jae Chel Lee, Yoo Sang Yoon, Dae Sung Kim, Moon Jun Na, Sun Jung Kwon, Dong Sun Kim, Jaeku Kang, Jae Yong Park, Ji Woong Son (2015), microRNA-146a inhibits epithelial mesenchymal transition in non–small cell lung cancer by targeting insulin receptor substrate 2 in lung cancer, International Journal of Oncology
  • Bradley Diehl, Mark A. LaPack, Tony Y. Wang, Robert E. Kottmeier, Stacey M. Kaneshiro, Michael C. Brandenstein, Yongchun Zhang, Yuk Chun Chiu, Seongkyu Yoon, Victor M. Saucedo (2015), A Biopharmaceutical Industry Perspective on Single-Use Sensors for Biological Process Applications, BioPharm International, 28 (4)
  • Priyank Shah, Namjoon Kim,  Zhuangrong  Huang,  Mahesh  Jayamanna,  Edwin Jahngen, David Ryan, Seongkyu Yoon, Robert F. Kovar, and Yongwoo Lee (2015), Environmentally Benign Synthesis of Vinyl Ester Resin from Biowaste Glycerin, RSC Advances, DOI: 10.1039/C5RA03254G
  • Rathore, , C. Calado, K. Gernaey, S. Yoon (2015), Editorial of special issues on Process Analytical Technology, Journal of Chemical Technology and Biotechnology
  • Lee, , J Carvell, K. Brorson, and S. Yoon* (2015), Dielectric spectroscopy-based estimation of VCD in CHO cell culture, Journal of Chemical Technology and Biotechnology, 23 SEP 2014 DOI: 10.1002/jctb.4522
  • Lee, , A. Christie, J. Starkey, E. Read, S Yoon* (2015), Intracellular metabolic flux analysis of  CHO  cells  supplemented  with  wheat  hydrolysates  for  improved  mAb production and cell-growth, Journal of Chemical Technology and Biotechnology (2014), 29 SEP 2014, DOI: 10.1002/jctb.4523


  • Ali Yousefian-Jazi, Jun-Hyung Ryu, Seongkyu Yoon, Jay Liu (2014), Decision Support in  Machine  vision  system  for  monitoring  of  TFT-LCD  glass  substrates manufacturing, Journal of Process Control (2014), pp. 1015-1023 DOI information: 10.1016/j.jprocont.2013.12.009


  • Bawn, , H. Lee, A. Downey, J. Xu, and S. Yoon* (2013) Metabolic-Sensing Characteristics  of    Absorption-Photometry    for    Mammalian    Cell    Cultures    in Biopharmaceutical Processes, Journal of Pharmaceutical Bioprocessing (2013), 1(3), 255-266
  • Bhoskar, , B. Belongia, R. Smith, S. Yoon, T. Carter, and J. Xu (2013), Free Light Chain  Content   in   Culture   Media   Reflects   Recombinant   Monoclonal   Antibody Productivity and Quality, Biotechnology Progress, DOI:10.1021/btpr.1767
  • Yoon S* (2013) Foreword, Journal of Pharmaceutical Bioprocessing (2013), 1(1), 1-2
  • Kamga, M, Lee, J. Liu, S. Yoon* (2013) Quantification of Protein Mixture in chromatographic separation using Multi-wavelength UV spectra, Biotechnology Progress 29(3), 664-71
  • Yoon, S*.,  Lee,  J.  Liu,  (2013), Quality  Characterization  and  Classification  of Engineered Stone Countertops Using Soft-sensor Based on Image Analysis I&EC DOI: 10.1021/ie303442r
  • Lee , C. Lawton, Y. Na and S. Yoon* (2013), Robustness of Chemometrics-based Feature Selection Methods in Early Cancer Detection and Biomarker Discovery, Statistical Application in Genetics and Molecular Biology, 12(2), 207–223


  • Lee, , A. Bawn, S. Yoon* (2012) Reproducibility, Complementary Measure of Predictability  for  Robustness  Improvement  of  Multivariate  Calibration  Models  via Variable Selections, Analytica Chimica Acta, 757 11-18
  • Lee, , A. Christie, J. Liu, S. Yoon* (2012) Estimation of raw material performance in mammalian cell culture  using  near  infrared  spectra  combined  with  chemometrics approaches, Biotechnology Progress, 28(3), 824-832
  • Lee, , A. Christie, J. Xu, S. Yoon* (2012) Data fusion based assessment of raw materials in mammalian cell-culture, Biotechnology and Bioengineering, 109(11), 2819-2828
  • Lee S. Yoon* (2012), Variability analysis of soy hydrolysate and its effects on mammalian cell culture performance using chemometric approach, Chemical Process Control VIII conference, Georgia (Conference Proceeding)
  • Yousefian A., S. Yoon, and J. Liu (2012), Automatic grading of TFT-LCD glass substrates using optimized support vector machines, Industrial and Engineering Chemistry Research, 51(33), 10731-10982


  • Yoon, and J. F. MacGregor (2004). Principal Component Analysis of Multiscale Data for Process Monitoring and Fault Diagnosis. AIChE J., 50(11), 2891-2903.
  • Yoon, , N. Kettaneh, S. Wold, W. Pepe, and J. Landry (2003), Process Monitoring and Statistical Process Control of HF Furnaces using PCA/PLS, 2003 NPRA Plant Automation and Decision Support System, San Antonio, TX., USA
  • Yoon, and J. F. MacGregor (2001). Fault Diagnosis with Multivariate Statistical Models, Part I: Using Steady-State Fault Signatures. J. of Process Control, 11. 387- 400.
  • Yoon, and J. F. MacGregor (2001). Incorporation of  external  information  into multivariate  PCA/PLS  models.  4th IFAC workshop on on-line fault detection and supervision in the chemical process industries (CHEMFAS-4),  June  7~8, Chejudo, Korea,
  • Yoon, and J. F. MacGregor (2001). Unifying PCA and multiscale approaches to fault detection and isolation. 6th IFAC symposium on dynamics and control of process systems (DYCOPS-6), June 4~6, Chejudo, Korea
  • Yoon, and J. F. MacGregor (2000). Reply to letter to the editor. AIChE J., 46(9), 1897-1899.
  • Yoon, and J. F. MacGregor (2000). Statistical and Causal Model-Based Approaches to Fault Detection and Isolation. AIChE J., 46(9), 1813-1824.
  • Yoon, and J.F. MacGregor (2000), Relationships between statistical and causal model based approaches to fault detection and isolation. In: Proc. Of international symposium on advanced control of chemical processes (ADCHEM 2000), June 14-16, Pisa, Italy, 81-86.
  • Yoon, , A. Dasgupta, and G. Miliares (1996), Realtime optimization boosts capacity of Korean olefins plant, Oil and Gas Journal, June 17, 36-41

Book chapters

  • Yoon, S., S. Galbraith, H. Liu, B. Cha, (2018), Flowsheet modeling of a continuous direct compaction process, Computer Aided Chemical Engineering 41, 121-139 edited by Singh and Yuan, Elsevier 
  • Yoon, (2018), Process Analytical Technology and Quality-by-Design for Animal Cell Culture”, Advanced Biotechnology Book Series, Wiley-Blackwell Biotechnology Series.
  • Yoon* (2014), Basic principles and application  trend  of  Quality  By  Design  in “Roadmap to Becoming Biopharmaceutical Leader”, Editors: Korean FDA, 2014 (in Korean)
  • Kamga, M, Lee, N. Kim, S. Yoon* (2014) Modeling of protein monomer/aggregate purification by hydrophobic interaction chromatography: application to column design and process optimization. In Continuous Processing in Pharmaceutical Manufacturing edited by Ganapathy Subramanian, Wiley-VCH 2014
  • Yoon, (2011), Multivariate Data Analysis in Biopharmaceutical Application in “PAT Applied in Biopharmaceutical Process Development and Manufacturing” edited by Duncan Low, Jose C. Menezes, and Cenk Undey

Invention disclosures & patents

  • Provisional Patent (M&E Ref. 118082-00801) on Distributed perfusion bioreactor system for continuous culture of biological cells (Inventors: Olivier Berteau, Apicells; David Sergeant: Ipratech; Seongkyu Yoon: UMass Lowell
  • WP-2317 Sustainable Green Vinyl Ester Resin (GVER) for Renewable Resources (Inventor: Akshay Kokil, Priyank Shah, Seongkyu Yoon, Robert Kovar, Yongwoo Lee)55