Our research focuses on the role of oxidative stress, inflammation and lipoproteins modification in atherosclerosis and related metabolic disorder syndromes.
We are also interested in clinical laboratory new method development and validation studies.
The goal of our current research is to outline the pathways responsible for the regulation of plasma lipoproteins and factors which are associated with increased risk for developing numerous metabolic disorders such as obesity, diabetes and cardiovascular diseases. Diet and life style, like exercise and sedentary life greatly impact lipoprotein metabolism and contribute to cardiovascular risk which is modulated by a group of inflammatory and oxidative stress markers.
We are also interested in the role of platelets and blood thrombosis factors in atherosclerosis.
Our lab also engages in development and validation of methods of potential diagnostic application.
Cell culture, animal models especially mouse lacking LDL receptors, dietary supplementation, molecular biology and chromatographic techniques are used in our lab.
Technical Expertise
Our Current Technical expertise includes but not limited to the following
Animal models:
Instrumentation:
Software:
Center for Population Health
Core Laboratory
Garelnabi Research Group is also the Core Lab for the Center for the Health Population.
The laboratory core provides analysis of nutrients, biomarkers and clinical Laboratory measurements.
Laboratory, located at the new UMass Lowell’s Emerging Technologies and Innovation Center (ETIC).
Services include
Metabolic Biomarkers
Clinical Chemistry Methods
Method verification and Validation Studies
The Core Lab can also perform new and existing method verification and validations studies for 510K submission.
Quality Assurances
Core Lab follow GLP and specific available QA methods on analytes of interest.
Follow commercial manufacturer QA regimen.
The Clinical & Laboratory Standards Institute (CLSI) approved guidelines as it apply.
Team
Undergraduate students
Rhea Cabrera
Andrew Carvalho
Eden Hok
Students completed undergraduate senior research projects:
The following undergraduate students have completed research training/projects in Garelnabi Research Lab:
Christopher Chhoa
Madeline Puccio
Thomas Wall
Research Group photo 2010
Graduated Lab Members
Halleh Mahini
Doctorate of Philosophy in Biomedical Engineering and Biotechnology, May 2015.
Education:
PhD Biomedical Engineering & Biotechnology, May 2015
MS Biomedical Engineering & Biotechnology 2011
University of Massachusetts Lowell
B.S. Biological Sciences, 2008
University of Massachusetts Lowell
Halleh Mahini presenting her work at the American Heart Association meeting in Chicago 2013
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Chinedu C. Ochin, MBBS, MS., Ph.D
EDUCATION
University of Massachusetts-Lowell
PhD (Biomedical Engineering and Biotechnology) May 2018
MS (Biomedical Engineering and Biotechnology) May 2014
Ebonyi State University-Nigeria MBBS (Medicine and Surgery) Sept 2006
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Pharmaceutical Sciences Program
Biochemistry Program
Current Clinical Laboratory Sciences Program Master Students 2018-2019
Undergraduate students who received Robert Niclosi Research Awards:
Graduate students who received graduate Research Awards:
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Recently Published Images from the Lab
Clin Biochem. 2013 Jan;46(1-2):12-9.
Fig. (2). Possible mechanism of Lp(a) in stroke. Shows a simplified schematic of the possible connection between Lp(a) and stroke. The LPA gene gets expressed and then the Lp(a) protein, gets assembled with ApoA1 and apoB either inside cells or outside in the plasma. The assembled Lp(a) circulates in the plasma and the small sized Lp(a) particles can bind certain Blood vessel proteins and clump together; Lp(a) inhibits plasmin which mediated the prevention of blood clot formation. Cardiovasc Hematol Disord Drug Targets. 2017;17(1):64-72.