Sayed IM, Vo DT, Alcantara J, Inouye KM, Pranadinata RF, Luo L, Boland CR, Goyal NP, Kuo DJ, Huang SC, Sahoo D, Ghosh P, Das S. Molecular Signatures for Microbe-Associated Colorectal Cancers. bioRxiv [Preprint]. 2024 May 27:2024.05.26.595902. doi: 10.1101/2024.05.26.595902. PMID: 38853996; PMCID: PMC11160670.
Achi SC, McGrosso D, Tocci S, Ibeawuchi SR, Sayed IM, Gonzalez DJ, Das S. Proteome profiling identifies a link between the mitochondrial pathways and host-microbial sensor ELMO1 following Salmonella infection. bioRxiv [Preprint]. 2024 May 3:2024.05.03.592405. doi: 10.1101/2024.05.03.592405. PMID: 38746404; PMCID: PMC11092768.
Broering MF, Tocci S, Sout NT, Reutelingsperger C, Farsky SHP, Das S, Sayed IM. Development of an Inflamed High Throughput Stem-cell-based Gut Epithelium Model to Assess the Impact of Annexin A1. Stem Cell Rev Rep. 2024 Jul;20(5):1299-1310. doi: 10.1007/s12015-024-10708-4. Epub 2024 Mar 18. PMID: 38498294.
Sayed IM, Chakraborty A, Das S. Assays with Patient-Derived Organoids to Evaluate the Impact of Microbial Infection on Base Excision Repair (BER) Enzymes. Methods Mol Biol. 2023;2701:157-172. doi: 10.1007/978-1-0716-3373-1_10. PMID: 37574481.
Ghosh P, Sinha S, Katkar GD, Vo D, Taheri S, Dang D, Das S, Sahoo D. Machine learning identifies signatures of macrophage reactivity and tolerance that predict disease outcomes. EBioMedicine. 2023 Aug;94:104719. doi: 10.1016/j.ebiom.2023.104719. Epub 2023 Jul 27. PMID: 37516087; PMCID: PMC10388732.
Jati S, Mahata S, Das S, Chatterjee S, Mahata SK. Catestatin: Antimicrobial Functions and Potential Therapeutics. Pharmaceutics. 2023 May 20;15(5):1550. doi: 10.3390/pharmaceutics15051550. PMID: 37242791; PMCID: PMC10220906.
Das S. Linking SARS-CoV-2 to the circadian clock. Nat Cell Biol. 2023 Mar;25(3):373-374. doi: 10.1038/s41556-023-01099-8. PMID: 36918694.
Sharma A*, Achi SC*, Ibeawuchi SR*, Anandachar MS, Gementera H, Chaudhury U, Usmani F, Vega K, Sayed IM, Das S. The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses. (*Contributed equally). Virulence. 2023 Dec;14(1):2171690. doi: 10.1080/21505594.2023.2171690. PMID: 36694274
Sayed IM, Bhattacharyya A, Das S. Editorial: Microbial sensing to control host immune responses. Front Microbiol. 2022 Oct 11;13:1054640. doi: 10.3389/fmicb.2022.1054640. PMID: 36304953; PMCID: PMC9593312.
Ghosh P, Campos VJ, Vo DT, Guccione C, Goheen-Holland V, Tindle C, Mazzini GS, He Y, Alexandrov LB, Lippman SM, Gurski RR, Das S, Yadlapati R, Curtius K, Sahoo D. AI-assisted discovery of an ethnicity-influenced driver of cell transformation in esophageal and gastroesophageal junction adenocarcinomas. JCI Insight. 2022 Sep 22;7(18):e161334. doi: 10.1172/jci.insight.161334. PMID: 36134663; PMCID: PMC9675486.
Tocci S, Ibeawuchi SR, Das S, Sayed IM. Role of ELMO1 in inflammation and cancer-clinical implications. Cell Oncol (Dordr). 2022 Aug;45(4):505-525. doi: 10.1007/s13402-022-00680-x. Epub 2022 Jun 6. PMID: 35668246
Ghosh P, Katkar GD, Shimizu C, Kim J, Khandelwal S, Tremoulet AH, Kanegaye JT; Pediatric Emergency Medicine Kawasaki Disease Research Group, Bocchini J, Das S, Burns JC, Sahoo D. An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease. Nature Commun. 2022 Aug 11;13(1):4729. doi: 10.1038/s41467-022-32479-7. PMID: 35953486
Achi SC, Karimilangi S, Lie D, Sayed IM, Das S. The WxxxE proteins in microbial pathogenesis. Crit Rev Microbiol. 2023 Mar;49(2):197-213. doi: 10.1080/1040841X.2022.2046546. Epub 2022 Mar 14. PMID: 35287539; PMCID: PMC9737147.
Quach A, Jayaratne RR, Lee BJ, Ibeawuchi SR, Lim E, Das S, Barrett KE. Diarrhoeal pathogenesis in Salmonella infection may result from an imbalance in intestinal epithelial differentiation through reduced Notch signalling. J Physiol. 2022 Apr;600(8):1851-1865. doi: 10.1113/JP282585. Epub 2022 Feb 16. PMID: 35100665.
Sayed IM, Ibeawuchi SR, Lie D, Anandachar MS, Pranadinata R, Raffatellu M, Das S. The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses. Gut Microbes. 2021 Jan-Dec;13(1):1991776. doi: 10.1080/19490976.2021.1991776. PMID: 34719317; PMCID: PMC8565811.
Long T, Abbasi N, Hernandez JE, Li Y, Sayed IM, Ma S, Iemolo A, Yee BA, Yeo GW, Telese F, Ghosh P, Das S, Huang WJM. RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine. Gut. 2022 Sep;71(9):1790-1802. doi: 10.1136/gutjnl-2021-324984. Epub 2021 Dec 1. PMID: 34853057; PMCID: PMC9156727.
Vo DT, Fuller MR, Tindle C, Anandachar MS, Das S, Sahoo D, Ghosh P. SPT6 loss permits the transdifferentiation of keratinocytes into an intestinal fate that resembles Barrett’s metaplasia. iScience. 2021 Sep 11;24(10):103121. doi: 10.1016/j.isci.2021.103121. PMID: 34622168; PMCID: PMC8481972.
Tindle, C., Fuller, M., Fonseca, A., Taheri, S., Ibeawuchi, S. R., Beutler, N., Katkar, G. D., Claire, A., Castillo, V., Hernandez, M., Russo, H., Duran, J., Crotty Alexander, L. E., Tipps, A., Lin, G., Thistlethwaite, P. A., Chattopadhyay, R., Rogers, T. F., Sahoo, D., Ghosh, P., … Das, S. (2021). Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19. eLife, 10, e66417. https://doi.org/10.7554/eLife.66417
Sahoo D, Swanson L, Sayed IM, Katkar GD, Ibeawuchi SR, Mittal Y, Pranadinata RF, Tindle C, Fuller M, Stec DL, Chang JT, Sandborn WJ, Das S, Ghosh P. Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease. Nat Commun. 2021 Jul 12;12(1):4246. doi: 10.1038/s41467-021-24470-5. PMID: 34253728; PMCID: PMC8275683.
Sayed IM, Tindle C, Fonseca AG, Ghosh P, Das S. Functional assays with human patient-derived enteroid monolayers to assess the human gut barrier. STAR Protoc. 2021 Jul 17;2(3):100680. doi: 10.1016/j.xpro.2021.100680. PMID: 34337445; PMCID: PMC8313751.
Sayed IM, El-Hafeez AAA, Maity PP, Das S, Ghosh P. Modeling colorectal cancers using multidimensional organoids. Adv Cancer Res. 2021;151:345-383. doi: 10.1016/bs.acr.2021.02.005. Epub 2021 Mar 26. PMID: 34148617; PMCID: PMC8221168.
Sahoo D, Katkar GD, Khandelwal S, Behroozikhah M, Claire A, Castillo V, Tindle C, Fuller M, Taheri S, Rogers TF, Beutler N, Ramirez SI, Rawlings SA, Pretorius V, Smith DM, Burton DR, Alexander LEC, Duran J, Crotty S, Dan JM, Das S, Ghosh P. AI-guided discovery of the invariant host response to viral pandemics. EBioMedicine. 2021 Jun;68:103390. doi: 10.1016/j.ebiom.2021.103390. Epub 2021 Jun 11. PMID: 34127431; PMCID: PMC8193764.
Bakowski MA, Beutler N, Wolff KC, Kirkpatrick MG, Chen E, Nguyen TH, Riva L, Shaabani N, Parren M, Ricketts J, Gupta AK, Pan K, Kuo P, Fuller M, Garcia E, Teijaro JR, Yang L, Sahoo D, Chi V, Huang E, Vargas N, Roberts AJ, Das S, Ghosh P, Woods AK, Joseph SB, Hull MV, Schultz PG, Burton DR, Chatterjee AK, McNamara CW, Rogers TF. Drug repurposing screens identify chemical entities for the development of COVID-19 interventions. Nat Commun. 2021 Jun 3;12(1):3309. doi: 10.1038/s41467-021-23328-0. PMID: 34083527; PMCID: PMC8175350.
Sharma A, Lee J, Fonseca AG, Moshensky A, Kothari T, Sayed IM, Ibeawuchi SR, Pranadinata RF, Ear J, Sahoo D, Crotty-Alexander LE, Ghosh P, Das S. E-cigarettes compromise the gut barrier and trigger inflammation. iScience. 2021 Jan 6;24(2):102035. doi: 10.1016/j.isci.2021.102035. PMID: 33537654; PMCID: PMC7841355.
Swanson L, Katkar GD, Tam J, Pranadinata RF, Chareddy Y, Coates J, Anandachar MS, Castillo V, Olson J, Nizet V, Kufareva I, Das S, Ghosh P. TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26895-26906. doi: 10.1073/pnas.2011667117. Epub 2020 Oct 14. PMID: 33055214; PMCID: PMC7604444.
Abbasi N, Long T, Li Y, Yee BA, Cho BS, Hernandez JE, Ma E, Patel PR, Sahoo D, Sayed IM, Varki N, Das S, Ghosh P, Yeo GW, Huang WJM. DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis. Life Sci Alliance. 2020 Aug 18;3(10):e202000772. doi: 10.26508/lsa.202000772. PMID: 32817263; PMCID: PMC7441524.
Sayed IM, Chakraborty A, Abd El-Hafeez AA, Sharma A, Sahan AZ, Huang WJM, Sahoo D, Ghosh P, Hazra TK, Das S. The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells. Cells. 2020 Aug 28;9(9):1980. doi: 10.3390/cells9091980. PMID: 32872214; PMCID: PMC7565382.
Kim Y, Quach A, Das S, Barrett KE. Potentiation of calcium-activated chloride secretion and barrier dysfunction may underlie EGF receptor tyrosine kinase inhibitor-induced diarrhea. Physiol Rep. 2020 Jul;8(13):e14490. doi: 10.14814/phy2.14490. PMID: 32652816; PMCID: PMC7354088.
Sayed IM, Sahan AZ, Venkova T, Chakraborty A, Mukhopadhyay D, Bimczok D, Beswick EJ, Reyes VE, Pinchuk I, Sahoo D, Ghosh P, Hazra TK, Das S. Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells. J Biol Chem. 2020 Aug 7;295(32):11082-11098. doi: 10.1074/jbc.RA119.009981. Epub 2020 Jun 9. PMID: 32518160; PMCID: PMC7415988.
Sayed IM, Suarez K, Lim E, Singh S, Pereira M, Ibeawuchi SR, Katkar G, Dunkel Y, Mittal Y, Chattopadhyay R, Guma M, Boland BS, Dulai PS, Sandborn WJ, Ghosh P, Das S. Host engulfment pathway controls inflammation in inflammatory bowel disease. FEBS J. 2020 Sep;287(18):3967-3988. doi: 10.1111/febs.15236. Epub 2020 Feb 20. PMID: 32003126; PMCID: PMC7390677.
Ghosh P, Swanson L, Sayed IM, Mittal Y, Lim BB, Ibeawuchi SR, Foretz M, Viollet B, Sahoo D, Das S. The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer. Life Sci Alliance. 2020 Feb 10;3(3):e201900481. doi: 10.26508/lsa.201900481. PMID: 32041849; PMCID: PMC7012149.
Sahan AZ, Hazra TK, Das S. The Pivotal Role of DNA Repair in Infection Mediated-Inflammation and Cancer. Front Microbiol. 2018 Apr 11;9:663. doi: 10.3389/fmicb.2018.00663. PMID: 29696001; PMCID: PMC5904280.
Das S, Jayaratne R, Barrett KE. The Role of Ion Transporters in the Pathophysiology of Infectious Diarrhea. Cell Mol Gastroenterol Hepatol. 2018 Mar 5;6(1):33-45. doi: 10.1016/j.jcmgh.2018.02.009. PMID: 29928670; PMCID: PMC6007821.
Sarkar A, Tindle C, Pranadinata RF, Reed S, Eckmann L, Stappenbeck TS, Ernst PB, Das S. ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection. J Infect Dis. 2017 Dec 19;216(12):1655-1666. doi: 10.1093/infdis/jix528. PMID: 29029244; PMCID: PMC5853658.