Resources

5:30 – 6:30 pm
Biology Department conference room, Olsen Hall

2018

Gage Lab – April 26th, 5:30 to 6:30 pm

Myopathies encompass a wide variety of acquired and hereditary disorders.

Presented by Chris Tsiros

The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties. In this study, we observed increased passive tension (PT) of skinned myofibers from patients with myofibrillar myopathy (MFM) caused by FLNC mutations (MFM-filaminopathy) and limb-girdle muscular dystrophy type-2A due to CAPN3 mutations (LGMD2A), compared to healthy control myofibers.

1. 1. 1. Article (PDF)
         • Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function

Moore Lab – January 30, 2018

Thick Filament in vitro motility

1. 1. 1. Article (PDF)
         • A mixed-kinetic model describes unloaded velocities of smooth, skeletal, and cardiac muscle myosin filaments in vitro

2016

Rishel Vohnoutka

Serine 493: The modulation site of Neurofilament Heavy Chain conformation and function within the neuron?

1. 1. 1. Articles
         • The Polymer Brush Model of Neurofilament Projections: Effect of Protein Composition
         • Neurofilaments at a glance

Nugent Lab

Heparan sulfate and heparin interactions with proteins by Divya Tsiros

1. 1. 1. Articles
         • Heparan sulfate and heparin interactions with proteins
         • Synergistic Binding of Vascular Endothelial Growth Factor-A and its Receptors to Heparin Selectively Modulates Complex Affinity

Giles Lab

Terahertz Imaging by Dr. Giles and Dr. Joseph

1. 1. Articles
      • Single-channel prototype terahertz endoscopic system
      • Imaging of ex vivo nonmelanoma skin cancers in the optical and terahertz spectral regions

Moore Lab

Optical Trapping and Myosin Mechanochemistry

1. 1. 1. Article
         • Inherent Force-Dependent Properties of b-Cardiac Myosin Contribute to the Force-Velocity Relationship of Cardiac Muscle
      2. Supplement
         • Figures as PowerPoint

2015

Gage Lab

Exploring the Role of the Intrinscially Disordered Region of Soluble Guanylyl Cyclase

1. 1. 1. Articles
         • Nitric Oxide–Independent Vasodilator Rescues Heme-Oxidized Soluble Guanylate Cyclase From Proteasomal Degradation
         • Thrombospondin-1 and Angiotensin II Inhibit Soluble Guanylyl Cyclase through an Increase in Intracellular Calcium Concentration
      2. PowerPoint Slides

Nugent Lab

Modification of fibronectin structure to regulate function

1. 1. 1. Article
         • Heparin-induced conformational changes of fibronectin within the extracellular matrix promote hMSC osteogenic differentiation
      2. Background
         • A Catalytic Role of Heparin within the Extracellular Matrix
         • How heparan sulfate modification of fibronectin enables growth factor guided migration of embryonic cells
         • Heparin-Mediated Conformational Changes in Fibronectin Expose Vascular Endothelial Growth Factor Binding Sites

Gage Lab

Models for Titin’s Role in Active Muscle

1. 1. 1. Articles
         • Is titin a ‘winding filament’?
         • A new paradigm for muscle contraction

Moore Lab

Expansion Microscopy

• • 1. Article PDF
    2. Supplement Files
       • Supplement PDF
       • Movie 1
       • Movie 2
       • Movie 3